My question revisited...

"How can a microorganism like gonococci persist in a human population when it is continuously exposed to the immune system, and thus should be killed?"


--N. gonorrhea: a model for bacterial infection...--

Somehow this bacterium must have learned to cope with our immune system since the bacteria is found in up to 1/250 of all individuals, depending on the geographical location!

WB01372_.gif (406 bytes)Gonorrhea Course of Infection

  • The bacteria first gain entry in to the human urethra
  • Then adheres to epithelial cells (cells on the surface)
  • Invade (enter them)
  • Arrive at the basal membrane where they cause an acute purulent infection that leads to..
  • Secretion of pus in infected males and...
  • Note, the symptoms of female gonorrhea are more discrete, thus making the disease difficult to diagnose.

petri2.jpg (16053 bytes)

WB01372_.gif (406 bytes)What we do in our defense... (Though, obviously not enough...)

  • Massive amounts of macrophages and neutrophils (also know as bacteria eaters) kill the gonococcal bacteria
  • We also raise antibodies to seek and aid in the destruction of the bacteria

 

The Answer...

I promised you genetics earlier, and I wasn't kidding!


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